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June 4, 2026International Journal of Molecular SciencesOpen Access

Metabolic Dysregulation, Inflammation, and Median Nerve Dysfunction in Patients with Type 2 Diabetes Mellitus with Carpal Tunnel Syndrome

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Authors

ASAdina StoianSCSimona CerneaCBClaudia Bănescu

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Overview

Cross-sectional study assesses CTS severity linked to metabolic and inflammatory parameters in T2DM, suggesting implications for patient management.

Key Points

  • The study aims to evaluate the relationship between the severity of carpal tunnel syndrome and various clinical, metabolic, and inflammatory factors in patients with type 2 diabetes mellitus.
  • Conducted a cross-sectional study with 123 patients diagnosed with T2DM.
  • Performed clinical evaluations and nerve conduction studies using electromyography.
  • Collected data on metabolic parameters, including HbA1c, glycemia, and inflammation markers.
  • 43.9% of patients presented moderate-to-severe carpal tunnel syndrome, with bilateral involvement in 21.95%.
  • Hemoglobin A1c levels were significantly higher in moderate-to-severe CTS patients (p = 0.004), indicating worse glycemic control.
  • Each 1% increase in HbA1c raised the risk of moderate/severe CTS by approximately 60%.

Cite This Study

Stoian et al. (2026) studied this question.

synapsesocial.com/papers/6a2117dfd499ed480b170b2chttps://doi.org/10.3390/ijms27114995
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Metabolic syndrome in carpal tunnel syndrome patients.2025
  2. 2The interrelationship between the frequency and severity of entrapment neuropathies and HbA1c in patients with diabetes in short and long term: A retrospective cohort study2025
  3. 3Secondary Carpal Tunnel Syndrome Due to Flexor Tenosynovitis in a Diabetic Patient2026
  4. 4Glucose Levels and Granulocyte Colony-Stimulating Factor May Partially Mediate the Association Between Genetic Liability to Diabetes and Carpal Tunnel Syndrome2026
  5. 5Surgical Release of the Carpal Tunnel in a Patient with Compressive Median Neuropathy: A Case Report2026