Key result
Among American Indian women, neither grand multiparity (OR 0.76; 95% CI 0.39-1.46) nor pregnancy complications (OR 1.08; 95% CI 0.62-1.88) were significantly associated with incident cardiovascular disease.
Why the study?
Cardiovascular disease is a leading cause of death among American Indian women in the United States, but associations of parity and pregnancy complications with incident cardiovascular disease in this population required investigation.
Do parity and pregnancy complications increase the risk of incident cardiovascular disease in American Indian women?
Cohort (n=1,203)
Do parity and pregnancy complications increase the risk of incident cardiovascular disease in American Indian women?
In a cohort of American Indian women, parity and pregnancy complications were not significantly associated with incident cardiovascular disease, though the study was limited by sample size.
Null findings should not alter CVD risk assessment by parity; larger studies needed to clarify associations in American Indian women.
Introduction: In the United States, cardiovascular disease (CVD) is a leading cause of death among American Indian women. We examined the associations of parity and pregnancy complications (history of preeclampsia, protein in urine, eclampsia or seizures, gestational diabetes, hypertension) with incident CVD (myocardial infarction, coronary heart disease, congestive heart failure, ischemic stroke) among American Indian women in the Strong Heart Family Study. Methods: Baseline information was collected between January 2006 and December 2009, and CVD events were evaluated through December 2022. We used clustered logistic regression analyses to assess associations of each parity or pregnancy complications with risk of CVD among women free of CVD at baseline ( N = 1,203). Results: We found no statistically significant association of parity with risk of CVD when comparing grand multiparous (≥5) women (OR = 0.76, 95% CI: 0.39, 1.46; p = 0.41) and moderate parous (2–4) women (OR = 1.33; 95% CI: 0.65, 2.71; p = 0.44) to low parous (0/1) women. We found no statistically significant association of pregnancy complications with risk of CVD (OR = 1.08, 95% CI: 0.62, 1.88; p = 0.78) comparing participants with no pregnancy complications to those with pregnancy complications. Conclusion: Although not statistically significant, findings support potential positive associations of grand multiparity and pregnancy complications with CVD among American Indian women. Given the limited sample size, more research is needed to assess the impact of multiparity and/or pregnancy complications on CVD risk among American Indians women.
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Ebadani et al. (2026) conducted a cohort in Cardiovascular disease (n=1,203). Pregnancy complications and parity vs. No pregnancy complications and low parity (0/1) was evaluated on Incident CVD (myocardial infarction, coronary heart disease, congestive heart failure, ischemic stroke) (OR 1.08, 95% CI 0.62, 1.88, p=0.78). Among American Indian women, neither grand multiparity (OR 0.76; 95% CI 0.39-1.46) nor pregnancy complications (OR 1.08; 95% CI 0.62-1.88) were significantly associated with incident cardiovascular disease.
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