Key result
Influenza vaccination induced reactive arthritis in a 79-year-old man, which improved with nonsteroidal anti-inflammatory drugs and resolved within 6 weeks.
Case Report (n=1)
Influenza vaccination can rarely induce reactive arthritis, which may be associated with HLA-B54 positivity and responds well to nonsteroidal anti-inflammatory drugs.
Rare case alerts to possible post-vaccination reactive arthritis; leaves open HLA-B54 link and causality for larger studies.
We describe a patient with reactive arthritis (ReA) induced by influenza vaccination. A healthy 79-year-old Japanese man began suffering from migrating polyarthritis 2 days after receiving influenza vaccine. He proved negative for rheumatoid factor, showing no evidence for microbial infections such as Streptoccocci, Chlamydia, or Parbovirus B19. Human leukocyte antigen (HLA) typing analysis revealed positive results for HLA-B54 (22), which is one of the cross-reactive antigens to HLA-B27. His arthritis improved with administration of nonsteroidal anti-inflammatory drugs, and recovery was attained within 6 weeks. Reactive arthritis is a rare adverse effect induced by influenza vaccination; however, it is important that it is recognized by all physicians.
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Asakawa et al. (2005) conducted a case report in Reactive arthritis (n=1). Influenza vaccination was evaluated on Reactive arthritis (migrating polyarthritis). Influenza vaccination induced reactive arthritis in a 79-year-old man, which improved with nonsteroidal anti-inflammatory drugs and resolved within 6 weeks.
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