In vivo antioxidant and anti-inflammatory properties of ethanol leaf extract of Ficus ottoniifolia Miq. on complete Freund’s adjuvant (CFA)-induced rheumatoid arthritis in albino rats

Key Points

• This research aims to explore the antioxidant and anti-inflammatory effects of Ficus ottoniifolia leaf extract on induced rheumatoid arthritis.
• Evaluated the impact of ethanol leaf extract of Ficus ottoniifolia on CFA-induced rheumatoid arthritis in albino rats.
• Used various biochemical assays to measure antioxidant and anti-inflammatory properties.
• Assessed changes in disease symptoms and related biomarkers.
• Significant reduction in inflammation markers was observed in treated rats compared to controls (p<0.05).
• Antioxidant activity increased significantly with extract treatment, leading to improved oxidative stress markers (p<0.01).
• Behavioral symptoms of arthritis improved notably in rats given the extract, indicating potential therapeutic benefits.