Population
C57BL/6J mice chronically instrumented with either femoral artery or right ventricular catheters.
Comparison
Acute hypoxia or 5 weeks of chronic intermittent… vs Baseline measurements prior to hypoxia exposure.
Design
Preclinical
Follow-up
5 weeks
Authors
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Supports distinct acute and chronic cardiac responses to hypoxia in mice; extends preclinical models but leaves open human translation.
In a murine model, acute hypoxia acutely loads the right heart, while chronic intermittent hypoxia induces mild to moderate systemic and pulmonary hypertension with biventricular hypertrophy.
Campen et al. (2005) studied this question.
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