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OBJECTIVES: To explore the trends and patterns of human papillomavirus (HPV) infection in mainland China from 2015 to 2025, and to investigate the distribution of non-infected populations. METHODS: HPV detection data were from 27,000 participating hospitals across 341 cities in all 31 provinces, covering 69.2% of hospitals in mainland China. A total of 33,750,381 women who underwent HPV testing between January 2015 and September 2025 were included. The distribution of 17 high-risk genotypes (HPV-16, -18, -26, -31, -33, -35, -39, -45, -51, -52, -53, -56, -58, -59, -66, -68, and -82) and 10 low-risk genotypes (HPV-6, -11, -40, -42, -43, -44, -55, -61, -81, and -83) was assessed by year, age group, and region, respectively. RESULTS: The overall prevalence of HPV infection was 21.81%, with high- and low-risk genotypes being 17.02% and 4.79%, respectively. HPV prevalence generally increased from 7.75% in 2015 to 22.48% in 2025, participants aged less than 20 years (81.46%) exhibited the highest HPV infection burden, and the overall HPV prevalence trended slightly higher in eastern China (22.66%). The most common genotypes were HPV-52 (3.20%), HPV-16 (2.19%), and HPV-53 (1.67%). 51.16% of the participants had infection with one HPV genotype. The distribution of non-infected populations differed across years, age groups, and regions. CONCLUSIONS: The prevalence of HPV infection shows an increasing trend in the past ten years among women in mainland China, with the predominant genotypes being HPV-52, HPV-16, and HPV-53. Our findings highlight the importance of scaling up the HPV vaccination nationwide particularly targeting the youth and eastern China.
Li et al. (Tue,) studied this question.