Why the study?
Does the contact electrode technique generate monophasic action potentials through local pressure depolarization of a circumscript volume of cells?
Population
10 Langendorff-perfused mouse hearts
Comparison
Miniaturized MAP probe inserted into the right… vs TAPs recorded at different distances from the…
Design
Preclinical
Authors
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Supports Franz hypothesis via local depolarization in animals; leaves open clinical translation for contact electrode MAPs.
Does the contact electrode technique generate monophasic action potentials through local pressure depolarization of a circumscript volume of cells?
This study provides the first direct experimental evidence supporting the 'Franz hypothesis' that monophasic action potentials are generated locally through pressure depolarization of a circumscript volume of cells.
Knollmann et al. (2002) studied this question.
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