Key result
Suboptimal health status linked to ~2.9-fold higher risk of cognitive impairment.
Why the study?
As a determinant of cardiovascular disease and stroke, suboptimal health status is hypothesized to be associated with cognitive impairment and dementia, but this relationship required investigation.
Is suboptimal health status associated with cognitive impairment in middle-aged and older Chinese adults?
Cross-Sectional (n=3,524)
No
Is suboptimal health status associated with cognitive impairment in middle-aged and older Chinese adults?
Suboptimal health status serves as a potentially modifiable risk marker for cognitive impairment in community-dwelling adults, highlighting the importance of early screening and health optimization.
Suboptimal health status may flag elevated cognitive risk in community adults; hypothesis-generating and requires prospective confirmation before practice change.
BACKGROUND: Suboptimal health status (SHS) is an intermediate health status between ideal health and illness. As a determinant of cardiovascular disease and stroke, SHS is hypothesized to be associated with the development of cognitive impairment and dementia. This study aimed to investigate whether individuals with SHS have poor cognitive ability based on a community-based cohort in northern Chinese population. METHODS: cohort 2015 in Tangshan City were investigated in this study. Cognitive function was measured with the Mini-Mental State Examination (MMSE). SHS level was evaluated using a self-reporting Suboptimal Health Status Questionnaire-25 (SHSQ-25). The relationship between SHS and cognitive function was analyzed with logistic regression analysis, by which odds ratio (OR) and 95% confidence interval (CI) were calculated. RESULTS: The prevalence of cognitive impairment was 3.4% (121/3524) in our study, with the prevalence rates of 1.9% (34/1750) among men and 4.9% (87/1774) in women. The medians of total score of MMSE were 28 (interquartile range (IQR) = 27-29) in the SHS group, and 29 (IQR = 27-30) in the ideal health group. Logistic regression analysis showed that SHS was significantly correlated with cognitive impairment (adjusted OR = 2.936, 95% CI = 1.428-6.033). With regard to gender, the OR was 5.067 (95% CI = 1.346-19.068) in men, which was higher than that in women (OR = 2.324, 95% CI = 1.130-4.779). CONCLUSIONS: SHS might be a risk factor for cognitive function in northern Chinese population. Early screening of SHS individuals, as well as urgent treatment of SHS might contribute to the prevention of cognitive impairment.
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Ding et al. (2020) conducted a cross-sectional in Cognitive impairment / Suboptimal health status (n=3,524). Suboptimal health status vs. Ideal health was evaluated on Cognitive impairment (measured by Mini-Mental State Examination) (OR 2.936, 95% CI 1.428-6.033). Suboptimal health status was associated with a significantly increased risk of cognitive impairment (adjusted OR 2.936) compared to ideal health in middle-aged and older Chinese adults.
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