In a pig model of reperfused acute myocardial infarction, a whole heart 19F integral > 200 and border zone SNR > 8 was associated with significantly less remote myocardial systolic wall thickening and larger end diastolic volume index.
In vivo 19F-CMR using perfluorocarbon nanoemulsions can noninvasively quantify regional monocyte/macrophage infiltration after acute myocardial infarction, which independently correlates with early adverse left ventricular remodeling.
Absolute Event Rate: 29.4% vs 59%
p-value: p=0.005
Abstract Inflammatory cell infiltration is central to healing after acute myocardial infarction (AMI). The relation of regional inflammation to edema, infarct size (IS), microvascular obstruction (MVO), intramyocardial hemorrhage (IMH), and regional and global LV function is not clear. Here we noninvasively characterized regional inflammation and contractile function in reperfused AMI in pigs using fluorine ( 19 F) cardiovascular magnetic resonance (CMR). Adult anesthetized pigs underwent left anterior descending coronary artery instrumentation with either 90 min occlusion ( n = 17) or without occlusion (sham, n = 5). After 3 days, in surviving animals a perfluorooctyl bromide nanoemulsion was infused intravenously to label monocytes/macrophages. At day 6, in vivo 1 H-CMR was performed with cine, T2 and T2* weighted imaging, T2 and T1 mapping, perfusion and late gadolinium enhancement followed by 19 F-CMR. Pigs were sacrificed for subsequent ex vivo scans and histology. Edema extent was 35 ± 8% and IS was 22 ± 6% of LV mass. Six of ten surviving AMI animals displayed both MVO and IMH (3.3 ± 1.6% and 1.9 ± 0.8% of LV mass). The 19 F signal, reflecting the presence and density of monocytes/macrophages, was consistently smaller than edema volume or IS and not apparent in remote areas. The 19 F signal-to-noise ratio (SNR) > 8 in the infarct border zone was associated with impaired remote systolic wall thickening. A whole heart value of 19 F integral ( 19 F SNR × milliliter) > 200 was related to initial LV remodeling independently of edema, IS, MVO, and IMH. Thus, 19 F-CMR quantitatively characterizes regional inflammation after AMI and its relation to edema, IS, MVO, IMH and regional and global LV function and remodeling.
Bönner et al. (Thu,) conducted a other in Acute Myocardial Infarction (n=22). 19F cardiovascular magnetic resonance with perfluorooctyl bromide nanoemulsion vs. Sham surgery / Low 19F signal was evaluated on Remote myocardial systolic wall thickening (p=0.005). In a pig model of reperfused acute myocardial infarction, a whole heart 19F integral > 200 and border zone SNR > 8 was associated with significantly less remote myocardial systolic wall thickening and larger end diastolic volume index.