Population
Male and female rats, 3-6 months and 22-24 months old, specifically single fibres from soleus and extensor…
Comparison
Ageing (22-24 months old) and gender differences vs Young rats (3-6 months old) and opposite gender
Design
Preclinical
Key result
In soleus muscle fibres expressing type I MyHC, the maximum velocity of unloaded shortening decreased by 40% with age (P < 0.001), with similar age-related changes observed in both male and female rats.
Authors
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Adds to rodent evidence of age-related type I fiber slowing independent of sex; leaves open human translation and sarcopenia relevance.
Ageing leads to a significant decrease in shortening velocity in slow-twitch soleus muscle fibers, independent of gender, highlighting conserved age-related functional decline in skeletal muscle.
p-value: p=< 0.001
Degens et al. (1998) studied this question. Age (old vs young) vs. Young rats (3-6 months) was evaluated on Maximum velocity of unloaded shortening (V0) and myosin heavy chain (MyHC) and light chain (MyLC) isoform composition (p=< 0.001). In soleus muscle fibres expressing type I MyHC, the maximum velocity of unloaded shortening decreased by 40% with age (P < 0.001), with similar age-related changes observed in both male and female rats.