The age-related decrease in contractile speed in slow muscle fibres may be due to changes in the properties of myosin with age.
Answers are grounded in this paper and cite their sources.
Age-related slowing in slow fibers may involve myosin changes; leaves open translation to human muscle performance.
The effect of age on the motor protein myosin was examined in a novel in vitro motility assay. Myosin was extracted from soleus fibres of young (3-6 month) and old (20-24 month) rats. All fibres expressed the type I myosin heavy chain (MyHC) and the slow isoforms of the myosin light chains (MyLCs). In vitro motility speed was significantly (P < 0.001) faster in the young adult (1.43 +/- 0.23 microm s-1) than in the aged group (1.27 +/- 0.23 microm s-1). The result indicates that the age-related decrease in contractile speed observed in slow fibres may be the effect of a change in the properties of myosin with age.
No takes yet. Share an insight, caveat, or question.
Höök et al. (1999) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: