Key result
Maximal force generation was ~20% lower in muscle fibers from aged rats (P=0.02), but myosin ATPase activity did not differ between aged and young rats (697 vs 686 microM/s; P=0.89).
Absolute Event Rate: 697% vs 686%
p-value: p=0.89
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Reduced force in aged rat fibers without ATPase change; leaves open non-myosin mechanisms in sarcopenia models and cautions mechanistic extrapolation.
Lowe et al. (2002) studied Age-associated decline in muscle function (n=63). Advanced age vs. Young age (8-12 months) was evaluated on Myosin ATPase activity (microM/s) (p=0.89). Maximal force generation was ~20% lower in muscle fibers from aged rats (P=0.02), but myosin ATPase activity did not differ between aged and young rats (697 vs 686 microM/s; P=0.89).
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