Key result
Asymmetric dimethylarginine (ADMA) is reviewed as a biomarker in nephrologic diseases to clarify its role and establish reference values across different populations.
Why the study?
What is the role of asymmetric dimethylarginine (ADMA) as a biomarker in nephrologic diseases?
What is the role of asymmetric dimethylarginine (ADMA) as a biomarker in nephrologic diseases?
This review synthesizes current knowledge on ADMA as a biomarker for endothelial dysfunction and cardiovascular risk in patients with chronic kidney disease.
ADMA may mark endothelial dysfunction and CV risk in CKD; leaves open standardized references and prospective validation before clinical adoption.
It is encouraging to observe that a search for publications on "asymmetric dimethylarginine (ADMA)" in PubMed, as updated on June 2016, yielded >2500 items, 24 years after a splendid paper published by Vallance et al in which the authors proposed that ADMA accumulation could be a cardiovascular risk factor in chronic kidney diseases. ADMA is the endogenous inhibitor of nitric oxide synthase and is related to endothelial dysfunction, which plays an important role in vascular damage elicited by various cardiometabolic risk factors. Although current knowledge suggests that ADMA has critical central roles in renal diseases, there are still unexplained details. The present article aims to provide a review on ADMA and its relation as a biomarker in nephrologic diseases. We aimed to systematize articles in which ADMA levels were assessed in order to clarify its role in many diseases and establish its reference values in different populations.
No takes yet. Share an insight, caveat, or question.
Mustafa Erinç Sitar (2016) conducted a review in Nephrologic diseases. Asymmetric dimethylarginine (ADMA) was evaluated. Asymmetric dimethylarginine (ADMA) is reviewed as a biomarker in nephrologic diseases to clarify its role and establish reference values across different populations.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: