Key result
This review summarizes current evidence on the safety and efficacy of the MitraClip procedure compared to medical therapy or surgical repair for severe secondary mitral regurgitation.
Why the study?
Recently published large randomized clinical studies evaluating MitraClip in secondary severe mitral regurgitation with heart failure have drawn different conclusions.
Does percutaneous mitral valve repair using the MitraClip improve outcomes in patients with heart failure who have secondary severe mitral regurgitation due to left ventricular dysfunction compared to medical therapy alone or surgical repair?
Does percutaneous mitral valve repair using the MitraClip improve outcomes in patients with heart failure who have secondary severe mitral regurgitation due to left ventricular dysfunction compared to medical therapy alone or surgical repair?
This review summarizes the conflicting evidence from recent large randomized trials regarding the efficacy of MitraClip for secondary severe mitral regurgitation in heart failure.
Conflicting evidence leaves MitraClip's role in secondary MR unresolved; further RCTs needed before practice change.
Patients with heart failure who have secondary severe mitral regurgitation due to left ventricular dysfunction have a poor prognosis, with high rates of rehospitalization and mortality. Percutaneous mitral valve repair using the MitraClip (Abbott) has been shown to be safe and effective in secondary severe mitral regurgitation with heart failure. The number of MitraClip procedures performed has increased significantly, as recently published large, randomized clinical studies have shown. However, these studies have drawn different conclusions. This review aims to summarize the current evidence for the MitraClip procedure and provide information for its safe and successful implementation, comparing the studies that examined the use of MitraClip versus medical therapy alone or surgical repair for severe secondary mitral regurgitation.
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Elbey et al. (2019) conducted a review in Secondary severe mitral regurgitation with heart failure. MitraClip vs. Medical therapy alone or surgical repair was evaluated. This review summarizes current evidence on the safety and efficacy of the MitraClip procedure compared to medical therapy or surgical repair for severe secondary mitral regurgitation.
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