Key result
Surgical correction of severe mitral regurgitation removes volume overload and unmasks pre-operative left ventricular and left atrial structural and functional disturbances.
Why the study?
Severe mitral regurgitation causes chronic volume overload with left atrial and left ventricular remodeling, and surgical repair removes this overload to unmask pre-operative structure and function disturbances.
How does surgical correction (mitral valve repair) affect left atrial remodeling in patients with severe primary mitral regurgitation?
How does surgical correction (mitral valve repair) affect left atrial remodeling in patients with severe primary mitral regurgitation?
This review highlights the importance of assessing left atrial remodeling and intrinsic function before and after surgical repair of primary mitral regurgitation.
Severe mitral regurgitation (MR) is a common valve disease which is associated with high mortality, if only managed medically. MR produces chronic and progressive volume overload with left atrial (LA) and left ventricular (LV) dilatation and dysfunction, atrial fibrillation (AF) and eventually myocardial fibrosis, irrespective of ejection fraction (EF). Surgical correction (mitral valve repair) of MR removes the volume overload, hence unmasks pre-operative LV structure and function disturbances, including reduced EF and global longitudinal and circumferential strain, as well as LA volume and strain. This review aims at describing LA remodeling before and after surgical repair.
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Lisi et al. (2022) conducted a review in Severe mitral regurgitation. Surgical correction (mitral valve repair) was evaluated on Left atrial remodeling before and after surgical repair. Surgical correction of severe mitral regurgitation removes volume overload and unmasks pre-operative left ventricular and left atrial structural and functional disturbances.
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