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Highlights the progressive structural remodeling in chronic primary MR; leaves open whether early intervention.
Chronic mitral regurgitation (MR) of primary origin is a volume overload condition involving progressive dilatation of the left atrium (LA) and left ventricle (LV). When severe, chronic primary MR is, in the vast majority of cases, associated with structural and functional myocardial abnormalities in both the LA and LV walls1,2, as well as with right ventricular (RV) dilatation/dysfunction. Although often preceded by symptoms3, in later stages, chronic severe MR may lead to atrial fibrillation, severe LV dysfunction and/or pulmonary arterial hypertension.
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Magné et al. (2019) studied this question.
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