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October 20, 1989Science149 citations

Toward Protein Tertiary Structure Recognition by Means of Associative Memory Hamiltonians

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MFMark S. FriedrichsPWPeter G. Wolynes

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Abstract

The statistical mechanics of associative memories and spin glasses suggests ways to design Hamiltonians for protein folding. An associative memory Hamiltonian based on hydrophobicity patterns is shown to have a large capacity for recall and to be capable of recognizing tertiary structure for moderately variant sequences.

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Cite This Study

Friedrichs et al. (1989) studied this question.

synapsesocial.com/papers/6a21239fdd404b250c9d14e0https://doi.org/10.1126/science.246.4928.371
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