Hemodynamics Is a Key Epigenetic Factor in Development of the Cardiac Conduction System

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Population

chick embryos

Comparison

increased or reduced hemodynamic loading vs normal development (controls)

Design

Preclinical

Authors

Discussion

Hypothesis-generating for load-dependent conduction maturation; leaves open translation to human congenital heart disease.

Population

chick embryos

Intervention

increased (conotruncal banding, CTB) or reduced (left atrial ligation, LAL) hemodynamic loading

Comparator

normal development (controls)

Outcome

timing of the topological shift marking maturation of the conduction system (spatiotemporal patterns of ventricular activation)

Hemodynamic load acts as a critical biophysical factor in the differentiation and functional maturation of the specialized cardiac conduction system.

Rečková et al. (2003) studied this question.

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