What question did this study set out to answer?

This research aims to reveal how Xin Su Ning affects ionic channels influencing cardiac action potentials.

February 6, 2019Frontiers in PharmacologyOpen Access

Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning

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Why the study?

Xin Su Ning prolongs ventricular action potential duration and suppresses amplitude, but its specific ionic channel mechanisms remained to be revealed.

Population

Isolated rat hearts and cell lines stably transfected with hNaV1.5 and hERG channels

Comparison

Xin Su Ning exposure across doses

Design

Preclinical electrophysiological study

Authors

TWTaiyi WangCalifornia Institute of Technology WXWeiwei XieAnhui Medical University JYJiahui YuNantong University

Discussion

Member takes

Implication

May underlie XSN antiarrhythmic effects via class I/III blockade; hypothesis-generating in animal models, leaves clinical translation open.

Key Points

This research aims to reveal how Xin Su Ning affects ionic channels influencing cardiac action potentials.
Clinical trial involving 861 patients to assess PVC inhibition rates of XSN and mexiletine.
Electrophysiological measurements in isolated rat ECG to observe changes in R and T wave amplitudes.
Assessment of XSN's effect on hNaV1.5 and hERG channels in transfected cell lines.
XSN and mexiletine showed PVC inhibition rates of 65.85% and 63.10%, respectively.
XSN significantly decreased R wave amplitude and increased T wave amplitude in ECG recordings.
XSN blocked hNaV1.5 channels with an IC50 of 0.184 ± 0.017 g/L and suppressed hERG channels with an IC50 of 0.34 ± 0.01 g/L.

Structured PICO

Population

Isolated rat models and cell lines stably transfected with hNaV1.5 and hERG channels

Intervention

Xin Su Ning (XSN)

Outcome

Effect on ECG parameters (R wave and T wave amplitude) and ion channel suppression (hNaV1.5 and hERG channels)surrogate

Xin Su Ning exerts antiarrhythmic effects through class I and class III properties by suppressing hNaV1.5 and hERG channels.

Cite This Study

Wang et al. (2019) studied this question.

synapsesocial.com/papers/6a212b20ffa0738687c3ce88 https://doi.org/10.3389/fphar.2019.00070

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Implication

May underlie XSN antiarrhythmic effects via class I/III blockade; hypothesis-generating in animal models, leaves clinical translation open.

Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Ion Channel Targeted Mechanisms of Anti-arrhythmic Chinese Herbal Medicine Xin Su Ning

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Also Consider