Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
May 1, 1992The Journal of Immunology

Lung injury after deposition of IgA immune complexes. Requirements for CD18 and L-arginine

View Full Paper
Ask AI
Bookmark
Share

Authors

MMMichael S. MulliganUniversity of WashingtonJWJeffrey S. WarrenAlbert Einstein College of MedicineCSC. Wayne SmithMonroe College

Discussion

Loading...

Member takes

Implication

Randomized trial evaluates IgA immune complex-induced lung injury, indicating distinct pathophysiological mechanisms.

Key Points

  • To investigate the pathophysiological events following the deposition of IgA immune complexes in the lungs.
  • Pretreatment of rats with human recombinant soluble complement receptor-1 to assess lung injury attenuation.
  • Intravenous administration of CD18 antibodies to evaluate protective effects against lung injury.
  • Immunohistochemical analysis to assess endothelial leukocyte adhesion molecule-1 up-regulation post-IgA complex deposition.
  • CD18 antibody treatment significantly reduced lung injury severity after IgA immune complex exposure.
  • L-arginine presence exacerbated lung injury, while its analog NG-monomethyl-L-arginine provided protection.
  • Up-regulation of endothelial leukocyte adhesion molecule-1 was observed, dependent on TNF-alpha after IgA deposition.

Cite This Study

Mulligan et al. (1992) studied this question.

synapsesocial.com/papers/6a212ceea2a97f3a085ac5cehttps://doi.org/10.4049/jimmunol.148.10.3086
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Acute Immunologic Pulmonary Alveolitis1974 · 228 citations
  2. 2Bronchial lesions in a high serum IgA mouse model: pulmonary venular IgA deposition and spatially distinct lymphoid cell aggregation2026
  3. 3Roles of beta 2 integrins of rat neutrophils in complement- and oxygen radical-mediated acute inflammatory injury1992 · 152 citations
  4. 4Hexamerization: explaining the original sin of IgG-mediated complement activation in acute lung injury2024 · 2 citations
  5. 5FcαRI-mediated neutrophil activation contributed to the pathogenesis of adult IgA vasculitis with nephritis2025 · 5 citations