Why the study?
Does normal pregnancy alter platelet behaviour and thromboxane production?
Does normal pregnancy alter platelet behaviour and thromboxane production?
Normal pregnancy is associated with a transient increase in platelet reactivity during the third trimester that normalizes by 12 weeks postpartum.
May warrant caution with peripartum antiplatelet therapy; leaves open effects on gestational thrombosis risk.
A longitudinal study of platelet behaviour (platelet aggregation and release reaction) in whole blood and of serum thromboxane B2 production was performed before, during and after normal pregnancy. The response of platelets to arachidonic acid and to adrenaline was significantly increased in the third trimester. Six weeks after delivery, values were still modestly increased but return to non-pregnant values was complete by 12 weeks. Serum thromboxane B2 production was unchanged throughout pregnancy and the puerperium.
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Louden et al. (1990) studied this question.
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