Why the study?
Does fluorouracil therapy induce myocardial ischemia or left ventricular dysfunction in patients with colorectal cancer?
Population
106 colorectal cancer patients completely resected and adjuvantly treated with fluorouracil and oxaliplatin…
Design
Cohort
Follow-up
2 weeks after cessation of the intended 12 treatment courses
Authors
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Adjuvant fluorouracil therapy in colorectal cancer induces subclinical myocardial neuroendocrine changes with increased NT-proBNP and lactic acid, but does not cause long-term left ventricular dysfunction.
Does fluorouracil therapy induce myocardial ischemia or left ventricular dysfunction in patients with colorectal cancer?
Adjuvant fluorouracil therapy in colorectal cancer induces subclinical myocardial neuroendocrine changes with increased NT-proBNP and lactic acid, but does not cause long-term left ventricular dysfunction.
Jensen et al. (2010) studied this question.
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