What question did this study set out to answer?

The aim is to understand the differential expression of chemokine receptors in T cells involved in rheumatoid arthritis.

Selective accumulation of CCR5+ T lymphocytes into inflamed joints of rheumatoid arthritis

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Investigates CCR5 expression in T lymphocytes in the joints of patients with rheumatoid arthritis, suggesting implications for inflammation.

The aim is to understand the differential expression of chemokine receptors in T cells involved in rheumatoid arthritis.
Examined CCR4 and CCR5 expression on T cells from rheumatoid arthritis patients and controls.
Compared T cell populations in peripheral blood and synovial fluid.
Analyzed cytokine production by CCR5+ CD4+ T cells in vitro.
Active rheumatoid arthritis patients showed decreased CCR5+ and CCR4+ CD4+ T cells in peripheral blood compared to controls.
The majority of T cells in synovial fluid of active RA patients expressed CCR5, indicating selective recruitment.
CCR5+ CD4+ T cells produced IFN-gamma but not IL-4 upon stimulation, highlighting their pro-inflammatory role.

Suzuki et al. (1999) studied this question.

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Investigates CCR5 expression in T lymphocytes in the joints of patients with rheumatoid arthritis, suggesting implications for inflammation.