Why the study?
Does ATF4 modulation affect skeletal myofiber atrophy during fasting in mouse models?
Population
Mouse skeletal muscle model of fasting-induced myofiber atrophy
Comparison
Modulation of ATF4 expression vs Control conditions
Design
Preclinical
Authors
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ATF4 modulation merits further study in muscle wasting; hypothesis-generating in mouse models only, no clinical implications yet.
Does ATF4 modulation affect skeletal myofiber atrophy during fasting in mouse models?
ATF4 is identified as a novel mediator of skeletal myofiber atrophy during starvation, acting through transcriptional regulation of growth suppression and stress signaling genes.
Ebert et al. (2010) studied this question.
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