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In patients with infection urea-splitting bacteria reside within the stones, protected from the action of antimicrobial agents. To achieve complete eradication of residual macroscopic particles, surgical removal is followed by renal irrigation with a multivalent, buffered organic acid solution while a bacteriologically sterile urine is maintained. In 14 consecutive cases followed for an average of 34 months, stones have not recurred. Antibacterial therapy was stopped in all patients within two to four weeks of discharge following surgery; only one patient, a paraplegic with an indwelling catheter, has had a urinary tract infection.
Norman J. Nemoy (Mon,) studied this question.