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The electrophysiologic changes of organophosphonate (OP)-produced acetylcholine (ACh) overload in atrial tissue was studied by computer simulation. Changes in the action potential dynamics due to the heterogeneity of the substrate resulting from OP deposition in the tissue were produced, and the conditions for the generation and persistence of reentry waves were determined. It was shown that modulation of cardiac cell membrane currents can be used to modulate conditions leading to reentry suggesting avenues to prophylaxis.
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Zoltani et al. (2003) studied this question.
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