November 1, 2000Journal of Applied Physiology

Effects of sevoflurane on the contractility of ferret ventricular myocardium

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Why the study?

Does sevoflurane affect contractility and relaxation in isolated ferret right ventricular papillary muscles?

Population

Isolated ferret right ventricular papillary muscles (n=17 total; n=9 in group 1, n=8 in group 2)

Comparison

Sevoflurane vs Low extracellular Ca2+ concentration

Design

Preclinical

Authors

ABAnna BartunekDeutsche Gesellschaft für Anästhesiologie und Intensivmedizin PHPhilippe R. HousmansMayo Clinic in Arizona

Discussion

Member takes

Implication

Does not warrant changes in anesthetic management; leaves open translation of myocardial effects to clinical settings.

Structured PICO

Does sevoflurane affect contractility and relaxation in isolated ferret right ventricular papillary muscles?

Population

Isolated ferret right ventricular papillary muscles (n=17 total; n=9 in group 1, n=8 in group 2)

Intervention

Sevoflurane (incremental concentrations 0-4.9% vol/vol)

Comparator

Low extracellular Ca2+ concentration (0.45-2.25 mM in steps of 0.45 mM)

Outcome

Isotonic and isometric variables of contractility and relaxationsurrogate

Sevoflurane exerts a concentration-dependent myocardial depressant effect, likely due to decreased intracellular calcium availability, while accelerating relaxation.

Cite This Study

Bartunek et al. (2000) studied this question.

synapsesocial.com/papers/6a21370dc462d13b4dc3bade https://doi.org/10.1152/jappl.2000.89.5.1778

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Effects of sevoflurane on the contractility of ferret ventricular myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Effects of sevoflurane on the contractility of ferret ventricular myocardium

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider