April 7, 2006Journal of the American Chemical Society178 citations

Palmerolide A, a Cytotoxic Macrolide from the Antarctic Tunicate Synoicum adareanum

TDThushara DiyabalanageUniversity of Peradeniya CACharles D. AmslerUniversity of Alabama at Birmingham JMJames B. McClintockUniversity of Alabama at Birmingham

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Abstract

Palmerolide A, a 20-membered macrocyclic polyketide bearing carbamate and vinyl amide functionality, was isolated from the tunicate Synoicum adareanum collected from the vicinity of Palmer Station on the Antarctic Peninsula. Palmerolide A displays potent and selective cytotoxicity toward melanoma (UACC-66 LC50 = 0.018 muM) and appears to operate via inhibition (IC50 = 2 nM) of V-ATPase.

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synapsesocial.com/papers/6a2137414e039c92ec9d0d0c https://doi.org/https://doi.org/10.1021/ja0588508

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