Why the study?
Does increased large artery stiffness cause peripheral resistance artery dysfunction in a mouse model?
Does increased large artery stiffness cause peripheral resistance artery dysfunction in a mouse model?
Increased large artery stiffness causes cerebral artery endothelial dysfunction by reducing nitric oxide bioavailability and increasing oxidative stress, while preserving skeletal muscle feed artery function.
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Cerebral arteries may show greater endothelial vulnerability to stiffness than skeletal muscle arteries; leaves open human translation.
Walker et al. (2015) studied this question.
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