Why the study?
Hypertension may cause renal cellular injury, but whether extracellular vesicles released by senescent nephron cells can be identified in the urine of hypertensive patients remained to be demonstrated.
Are levels of urinary p16+ extracellular vesicles elevated in patients with hypertension compared to healthy volunteers?
Population
Patients with essential hypertension, renovascular hypertension, and healthy volunteers (n=14 each)
Comparison
Essential hypertension vs renovascular hypertension vs healthy volunteers
Authors
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May support p16+ EVs as senescence marker in hypertension; hypothesis-generating, needs prospective validation before clinical use.
Are levels of urinary p16+ extracellular vesicles elevated in patients with hypertension compared to healthy volunteers?
Urinary p16+ extracellular vesicles are elevated in hypertensive patients and may serve as a non-invasive biomarker for identifying intrarenal cellular senescence.
Santelli et al. (2019) studied this question.
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