Prostaglandin E2 Promotes Integrin αVβ3-dependent Endothelial Cell Adhesion, Rac-activation, and Spreading through cAMP/PKA-dependent Signaling

Olivier Dormond; Manuela Bezzi; Agnese Mariotti; Curzio Rüegg

doi:10.1074/jbc.m209213200

November 1, 2002Journal of Biological ChemistryOpen Access

Prostaglandin E2 Promotes Integrin αVβ3-dependent Endothelial Cell Adhesion, Rac-activation, and Spreading through cAMP/PKA-dependent Signaling

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Structured PICO

P

Population

human umbilical vein endothelial cells (HUVEC) model

I

Intervention

PGE2, TXA2 agonist U46619, cAMP analogue 8-brcAMP, and COX-2 inhibitor NS-398

O

Outcome

αVβ3-mediated endothelial cell adhesion, Rac activation, and cell spreadingsurrogate

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Implication

PGE2 accelerates αVβ3-mediated endothelial cell adhesion through cAMP-dependent PKA activation and induces αVβ3-dependent spreading via cAMP- and PKA-dependent Rac activation, providing mechanistic insights into tumor angiogenesis and inflammation.

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Cite This Study

Dormond et al. (2002) studied this question.

synapsesocial.com/papers/6a213943ffa0738687c3d902 https://doi.org/10.1074/jbc.m209213200

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Prostaglandin E2 Promotes Integrin αVβ3-dependent Endothelial Cell Adhesion, Rac-activation, and Spreading through cAMP/PKA-dependent Signaling

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

Prostaglandin E2 Promotes Integrin αVβ3-dependent Endothelial Cell Adhesion, Rac-activation, and Spreading through cAMP/PKA-dependent Signaling

Structured PICO

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Implication

Abstract

Discussion

Cite This Study

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