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Medicinal plant-derived natural bioactives have drawn a lot of interest due to their potential as a treatment for glaucoma. Flavonoids, terpenoids, and alkaloids are among the phytochemicals with neuroprotective, anti-inflammatory, and antioxidant qualities that might reduce damage to retinal ganglion cells. Important plant-based substances, including bilberry (Vaccinium myrtillus), Ginkgo biloba, Cannabis sativa, Panax ginseng, Scutellaria baicalensis Georgi, and Coleus forskohlii, have shown promise in lowering Intraocular Pressure (IOP) and preventing neurodegeneration brought on by oxidative stress. These bioactive work by modifying oxidative stress biomarkers, including SOD, GS, 8-OHdG, MDA, PC, NO, and AGEs, as well as inflammation biomarkers like MMP-9, VEGF, TNF-alpha, IL-5, IL-12, IL-15, IFN-γ, MCP-1, and IL-8. They protect retinal ganglion cells by scavenging free radicals, lowering inflammatory mediators, and improving ocular blood flow. More studies into formulation techniques and bioavailability improvement are essential in creating successful plant-based therapies, as there is growing evidence that natural chemicals can help treat glaucoma. Our study highlights the need for more investigation into clinical trials to improve the bioavailability and therapeutic effectiveness of these plant-derived bioactives in treating glaucoma. Major Findings: Natural compounds, such as Ginkgo biloba, baicalein, forskolin, and ginsenosides, exhibit significant potential, having neuroprotective, antioxidant, and IOP-lowering effects in the management of glaucoma.
Divya et al. (Fri,) studied this question.