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The mouse model appears to be a useful technique for assessing the pharmacological properties of antispasmodic agents in vivo. Phenoxybenzamine has an extended action in arterial grafts in vivo. Verapamil/nitroglycerin is short-lived in vivo but lasts longer in vitro. Measurements of antispasmodic duration of action in vitro should be interpreted with caution.
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Sandee McClowry (Sat,) studied this question.
synapsesocial.com/papers/6a213babc4e60624665ad2c0 — DOI: https://doi.org/10.1016/j.ejcts.2004.06.018
Sandee McClowry
Brooklyn Hospital Center
Merrill-palmer Quarterly
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