Tumor volume reduction ≤25% following preoperative radiotherapy for myxoid liposarcoma was associated with worse 10-year disease-specific survival compared to >25% reduction (37% vs 86%, p<0.01).
Cohort (n=62)
Does the degree of tumor volume reduction following preoperative radiotherapy predict disease specific survival in patients with myxoid liposarcoma?
Lack of tumor volume reduction (≤25%) following preoperative radiotherapy is a significant risk factor for metastatic disease and worse survival in patients with myxoid liposarcoma.
Hazard Ratio: 4.52
Absolute Event Rate: 37% vs 86%
p-value: p=< 0.01
BACKGROUND: Compared to other sarcomas, myxoid liposarcoma (ML) is known to be radiosensitive, with improved oncologic outcomes. Although these tumors "shrink" following radiotherapy, there is a paucity of data examining the degree of radiosensitivity and oncologic outcome. The purpose of the study was to evaluate pre- and postradiotherapy tumor volume to determine if size reduction impacts outcome. METHODS: We reviewed 62 patients with ML undergoing surgical resection combined with preoperative radiotherapy, with pre- and postradiotherapy MRI. This included 34 (55%) males, with a mean age of 47 ± 14 years. All tumors were deep to the fascia, and 12 (19%) patients had tumors with a >5% round-cell component. RESULTS: The mean volume reduction was 54% ± 29%. Compared to patients with >25% volume reduction, patients with reduction ≤25% had worse 10-year disease specific survival (86% vs. 37%, p < 0.01), in addition to an increased risk of metastatic disease (HR 4.63, p < 0.01) and death due to disease (HR 4.52, p < 0.01). CONCLUSION: Lack of volume reduction is a risk factor for metastatic disease and subsequent death due to disease in patients with extremity ML treated with combined preoperative radiotherapy and surgery. This data could be used to stratify patients for adjuvant therapies and follow-up intervals.
Houdek et al. (Tue,) conducted a cohort in Myxoid liposarcoma (n=62). Tumor volume reduction ≤25% vs. Tumor volume reduction >25% was evaluated on 10-year disease specific survival (HR 4.52, p=< 0.01). Tumor volume reduction ≤25% following preoperative radiotherapy for myxoid liposarcoma was associated with worse 10-year disease-specific survival compared to >25% reduction (37% vs 86%, p<0.01).