Endothelial Dysfunction Is Detectable in Young Normotensive First-Degree Relatives of Subjects With Type 2 Diabetes in Association With Insulin Resistance

53 normotensive first-degree relatives (FDRs) of patients with type 2 diabetes mellitus (21 men, 32 women; mean age, 35 years) with normal oral glucose tolerance, 10 age- and sex-matched normal control subjects, and 25 DM patients (mean age, 57 years).

Normal control subjects and DM patients, as well as comparisons across tertiles of insulin resistance among FDRs.

Endothelium-dependent and -independent vasodilation of the brachial artery measured with high-resolution ultrasound.surrogate