Key result
Abnormal mental capacity in elderly anticoagulated patients was associated with more time outside the therapeutic range than matched controls (20.9% vs 13.7%; OR 1.68; 95% CI 1.53-1.84; P<0.0001).
Why the study?
Does reduced mental ability increase the time spent outside the intended therapeutic range in elderly patients receiving oral anticoagulant treatment?
Population
311 apparently self-sufficient patients under stabilised oral anticoagulant treatment
Comparison
Abnormal mental capacity vs Normal mental capacity
Design
Case-control
Follow-up
6 months
Authors
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May support cognitive screening in elderly on anticoagulation; leaves open whether it improves TTR or outcomes.
Case-Control (n=311)
Does reduced mental ability increase the time spent outside the intended therapeutic range in elderly patients receiving oral anticoagulant treatment?
Odds Ratio: 1.68 (95% CI 1.53–1.84)
Absolute Event Rate: 20.9% vs 13.7%
p-value: p=< 0.0001
Unsuspected reduction in mental ability in elderly patients on oral anticoagulation is associated with poorer INR control, highlighting the need for cognitive assessment to mitigate risks of thrombotic or bleeding complications.
Palareti et al. (1997) conducted a case-control in Oral anticoagulant treatment (n=311). Abnormal mental capacity (abnormal AMT score) vs. Normal mental capacity (matched controls) was evaluated on Percentage of time spent outside the intended therapeutic range (OR 1.68, 95% CI 1.53-1.84, p=< 0.0001). Abnormal mental capacity in elderly anticoagulated patients was associated with more time outside the therapeutic range than matched controls (20.9% vs 13.7%; OR 1.68; 95% CI 1.53-1.84; P<0.0001).
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