Key result
Lower GFR is linked to ~6% higher all-cause mortality per 10-unit drop in LV dysfunction.
Why the study?
Do reduced kidney function and anemia increase the risk of all-cause mortality in patients with left ventricular dysfunction?
Population
Patients with left ventricular (LV) dysfunction from the Studies Of LV Dysfunction (SOLVD) database
Comparison
Reduced kidney function and anemia vs Higher GFR and higher hematocrit
Design
Cohort
Authors
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Decreased kidney function and anemia are independent and interacting risk factors for all-cause mortality in patients with left ventricular dysfunction.
Cohort
Do reduced kidney function and anemia increase the risk of all-cause mortality in patients with left ventricular dysfunction?
Hazard Ratio: 1.064 (95% CI 1.033–1.096)
Decreased kidney function and anemia are independent and interacting risk factors for all-cause mortality in patients with left ventricular dysfunction.
Al‐Ahmad et al. (2001) conducted a cohort in Left ventricular (LV) dysfunction. Reduced kidney function (lower GFR) and lower hematocrit vs. Higher GFR and hematocrit was evaluated on All-cause mortality (HR 1.064, 95% CI 1.033-1.096). Lower GFR (HR 1.064 per 10 ml/min/1.73 m2 decrease) and lower hematocrit (HR 1.027 per 1% decrease) were associated with increased all-cause mortality in patients with LV dysfunction.
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