Key result
Evaluation of 20 chronic schizophrenic men showed increased P300 latency, ventricular enlargement, and global neuropsychological impairment, with poor performance associated with delayed P300.
Population
20 chronic male schizophrenic subjects aged 30-50 years
Design
Cross-sectional
Authors
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P300 latency may mark cognitive impairment better than ventricular enlargement in schizophrenia; hypothesis-generating and requires prospective validation.
Cross-Sectional (n=20)
In chronic male schizophrenic patients, cognitive impairment correlates with delayed P300 latencies rather than structural brain changes on CT scan.
Romani et al. (1987) conducted a cross-sectional in Chronic Schizophrenia (n=20). Auditory event-related potential (P300) and CT scan was evaluated on P300 latency and amplitude, CT scan measures, and neuropsychological performance. Evaluation of 20 chronic schizophrenic men showed increased P300 latency, ventricular enlargement, and global neuropsychological impairment, with poor performance associated with delayed P300.
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