November 1, 1996British Journal of PharmacologyOpen Access

Inhibitory effects of fluvastatin, a new HMG‐CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol‐fed rabbits

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Why the study?

Does fluvastatin reduce vascular ACE activity and atherosclerosis progression in hyperlipidaemic rabbits?

Structured PICO

Does fluvastatin reduce vascular ACE activity and atherosclerosis progression in hyperlipidaemic rabbits?

Population

Rabbits fed a 1.5% cholesterol containing diet or normal diet

Intervention

Fluvastatin 2 mg kg-1 day-1 in the diet for 16 weeks

Comparator

Enalapril 10 mg kg-1 day-1 in the diet, or no treatment (hyperlipidaemic control)

Outcome

Vascular ACE activity in the aortic arches and upper thoracic aortaesurrogate

Fluvastatin decreases vascular ACE activity and lipid peroxidation in hyperlipidaemic rabbits, suggesting a mechanism for reducing atherosclerosis progression beyond its lipid-lowering effects.

Discussion

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Implication

Hypothesis-generating for statin pleiotropy on vascular ACE; leaves open translation to human atherosclerosis prevention.

Cite This Study

Mitani et al. (1996) studied this question.

synapsesocial.com/papers/6a21436fa2a97f3a085ae050 https://doi.org/10.1111/j.1476-5381.1996.tb16032.x

Topics

Statin therapy

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Inhibitory effects of fluvastatin, a new HMG‐CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol‐fed rabbits

Structured PICO

Discussion

Implication

Cite This Study

Topics

Inhibitory effects of fluvastatin, a new HMG‐CoA reductase inhibitor, on the increase in vascular ACE activity in cholesterol‐fed rabbits

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider