Therapy of Recurrent Invasive Urinary-Tract Infections of Men

THERE has been new interest in the therapy of urinary-tract infections, and new treatment programs have evolved.1 , 2 Men with recurrent urinary-tract infections present a formidable therapeutic challenge.3 , 4 Presumably short courses of antibiotic therapy fail to eradicate foci of infection that are frequently associated with structural abnormalities within the prostatic and renal parenchyma. We undertook a randomized, double-blind, placebo-controlled study to determine whether an extended course of therapy for men with recurrent, invasive urinary-tract infections would be more effective than the conventional two-week course of therapy. We found that a six-week course of antimicrobial therapy resulted in fewer relapses than the . . .