A 45-year-old man presented with a 4-month history of progressive fatigue, lethargy, shortness of breath on exercise, and generalized numbness with paresthesias. Initial bloodwork showed severe pancytopenia, with a hemoglobin of 4.9 g/dL, a white blood cell count of 1,000 mm−3, and a platelet count of 121,000 mm−3. Bone marrow biopsy showed aplastic anemia with ringed sideroblasts. This was subsequently attributed to zinc toxicity with associated copper deficiency. His serum zinc level was 192 μg/dL (normal, 70 to 150 μg/dL), his serum copper level was 0 μg/dL (normal, 70 to 155 μg/dL), and his serum ceruloplasmin level was 6.8 mg/dL (normal, 16.2 to 35.6 mg/dL). Blood levels of other heavy metals, including lead, mercury, and arsenic, were normal. He was transfused with 4 …
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Prodan et al. (2000) studied this question.
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