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February 10, 2005Physical Review Letters328 citations

Colloidal Interactions and Self-Assembly Using DNA Hybridization

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PBPaul L. BiancanielloAKAnthony J. KimJCJohn C. Crocker

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Abstract

The specific binding of complementary DNA strands has been suggested as an ideal method for directing the controlled self-assembly of microscopic objects. We report the first direct measurements of such DNA-induced interactions between colloidal microspheres, as well as the first colloidal crystals assembled using them. The interactions measured with our optical tweezer method can be modeled in detail by well-known statistical physics and chemistry, boding well for their application to directed self-assembly. The microspheres' binding dynamics, however, have a surprising power-law scaling that can significantly slow annealing and crystallization.

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Biancaniello et al. (2005) studied this question.

synapsesocial.com/papers/6a2147b3d96c1a33c45ad48fhttps://doi.org/10.1103/physrevlett.94.058302
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