This review summarizes cardiac involvement and dysfunction in four major groups of muscular dystrophies.
uscular dystrophy (MD) connotes a heterogeneous group of inherited disorders characterized by progressive wasting and weakness of the skeletal muscles. In several forms of MD, cardiac dysfunction occurs, and cardiac disease may even be the predominant manifestation of the underlying genetic myopathy. 3] his review will focus on 4 groups of skeletal muscle disease most commonly associated with cardiac complications (the Table ): (1) dystrophin-associated diseases such as Duchenne and Becker (DMD and BMD, respectively), (2) Emery-Dreifuss MD (EDMD), (3) limb-girdle MD (LGMD), and (4) myotonic dystrophy (DM).
Verhaert et al. (Sat,) studied this question.