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VF induction confined to relative refractory period in dogs; leaves open translation to human arrhythmia mechanisms and defibrillation.
Vulnerability to ventricular fibrillation has been studied in 20 dogs by means of test stimuli of known strength and duration in order to ascertain the relationship between the vulnerable period and the recovery of excitability and to determine the effects of countershock defibrillation. The relative refractory period is found to be the only portion of the cycle during which fibrillation could be produced by this technique. Defibrillation was accomplished without producing significant changes in vulnerability or excitability.
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Hoffman et al. (1955) studied this question.
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