Why the study?
Does macrophage migration inhibitory factor (MIF) correlate with other angiogenic biomarkers in patients with pulmonary arterial hypertension?
Does macrophage migration inhibitory factor (MIF) correlate with other angiogenic biomarkers in patients with pulmonary arterial hypertension?
MIF shows significant positive correlations with several angiogenic factors in PAH, suggesting a potential regulatory role in PAH angiogenesis and pathobiology.
MIF-angiogenic correlations in PAH are hypothesis-generating; leaves open mechanistic and prognostic roles pending longitudinal validation.
Macrophage migration inhibitory factor (MIF) and 22 a priori selected biomarkers were measured from pulmonary arterial hypertension (PAH) patients. Significant positive correlations were found between MIF and several angiogenic factors suggesting a possible MIF regulation role in PAH angiogenesis and pathobiology, but simultaneously highlighting the biomarkers profiling complexity in PAH.
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Marshall et al. (2017) studied this question.
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