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This research aims to understand how schistosome infections affect T cell responses during chronic infection stages.

A Novel Host-Parasite Lipid Cross-talk

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This research aims to understand how schistosome infections affect T cell responses during chronic infection stages.
Analysis of T cell hyporesponsiveness during schistosome infection stages.
Use of mass spectrometry to identify lyso-PS as the TLR2-activating molecule.
Investigation of the effects on dendritic cells and IL-10-producing regulatory T cell development.
Schistosoma-specific phosphatidylserine activated TLR2 in dendritic cells.
Mature dendritic cells induced IL-10-producing regulatory T cells after lyso-PS exposure.
Synthetic lyso-PS (16:0) and host-derived PS did not activate TLR2, indicating specificity of schistosomal lyso-PS.

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Novel findings reveal schistosomial lyso-PS activates TLR2 in dendritic cells, implying key host-parasite communication.

Kleij et al. (2002) studied this question.

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