Mobility of carbohydrate containing sites on the surface membrane in relation to the control of cell growth

1, lntr,odamfionMolecules that bind specifically to carbohydrate contaiNng si~es on the smface membrane can be used t~ elucidate changes .i~ the smfaee membrane associ~ -ated wilh changes ~n ~h,e regulation of cell growIh.IAsing as a probe th~ earbDhydraIe-binding protein concana~a]in A (Con.A) diffe,iences between normal and malignant tmnffozmed cells bare been shown fin Con.A~indaced cell agglutinab~hty f 175], thb number a~'ad distr~bufi.on of Con.A Mnding site~ ~6-9], th.e location of amino acid and cmbohyd,mte transpOlt -si~es I10], Con.A induced e~l ~oyA,ci~ ~I11--13], the mobility of Con.A binding sit.as 114, 15].and membrane stability and the ]eve] of cellular ATP II 1,6], Changes in ~he di~fibuiion Of Con,A binding Sties I7, 14, 15] and the movement of antigens on the cell ~r "9