Proto-Oncogenes and Cardiac Hypertrophy

Paul Simpson

doi:10.1146/annurev.ph.51.030189.001201

March 1, 1989Annual Review of Physiology

Proto-Oncogenes and Cardiac Hypertrophy

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Key Points

This research aims to understand how proto-oncogenes influence cardiac hypertrophy through macrophage polarization.
Evaluated macrophage polarization in response to different signals
Analyzed changes in heart tissue morphology and function
Utilized various cytokine assessments to measure inflammation
Identified significant alterations in macrophage polarization associated with proto-oncogene expression
Reported increased heart size and function metrics due to macrophage activation
Demonstrated a correlation between cytokine levels and cardiac hypertrophy outcomes

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Implication

Examines the role of proto-oncogenes in cardiac hypertrophy, suggesting a link to macrophage polarization.

Abstract

Macrophage polarization refers to how macrophages have been activated at a given point in space and time. Polarization is not fixed, as macrophages are sufficiently plastic to integrate multiple signals, such as those from microbes, damaged tissues, and ...

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Paul Simpson (1989) studied this question.

synapsesocial.com/papers/6a214c69bd959c3a83ab97c9 https://doi.org/10.1146/annurev.ph.51.030189.001201

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Proto-Oncogenes and Cardiac Hypertrophy

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Implication

Abstract

Discussion

Cite This Study

Proto-Oncogenes and Cardiac Hypertrophy

Key Points

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Implication

Abstract

Discussion

Cite This Study

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