What question did this study set out to answer?

To identify cytogenetic features predicting outcomes in children with high hyperdiploid acute lymphoblastic leukemia.

Prognostic Impact of Trisomies of Chromosomes 10, 17, and 5 Among Children With Acute Lymphoblastic Leukemia and High Hyperdiploidy (> 50 Chromosomes)

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Randomized trial identifies trisomies 10 and 17 as improving outcomes in children with high hyperdiploidy, suggesting new prognostic markers.

To identify cytogenetic features predicting outcomes in children with high hyperdiploid acute lymphoblastic leukemia.
Enrolled high-hyperdiploid ALL patients (N = 480) on CCG trials (1988-1995)
Karyotypes determined by conventional banding
Outcomes analyzed using life-table methods
Patients with 54-58 chromosomes had significantly better outcomes than those with other counts (P = .0002)
Trisomy of chromosome 10 (P < .0001) and 17 (P = .0002) improved outcomes; trisomy of chromosome 5 worsened outcomes (P = .02)
Multivariate analysis showed trisomy 10 as the most significant prognostic factor (P = .001)

Heerema et al. (2000) studied this question.

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Randomized trial identifies trisomies 10 and 17 as improving outcomes in children with high hyperdiploidy, suggesting new prognostic markers.