Key result
Novel nomogram achieves ~0.85 C-index, outperforming Khorana score for VTE prediction in solid cancer.
Why the study?
Cancer patients with venous thromboembolism face poor prognoses, motivating the development of a nomogram to predict VTE risk in this population.
Does a novel nomogram better predict the risk of venous thromboembolism in patients with solid cancers compared to the Khorana score?
Population
791 patients diagnosed with solid tumors at Tongji Hospital
Comparison
Developed nomogram vs Khorana score
Design
Retrospective study
Authors
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Nomogram outperformed Khorana score but should not yet change practice; leaves open prospective validation for VTE risk stratification in solid cancers.
Case-Control (n=791)
No
Does a novel nomogram better predict the risk of venous thromboembolism in patients with solid cancers compared to the Khorana score?
Absolute Event Rate: 0.852% vs 0.681%
p-value: p=<0.05
A novel nomogram incorporating clinical and laboratory variables demonstrated superior predictive accuracy for venous thromboembolism in patients with solid cancers compared to the Khorana score.
Chen et al. (2023) conducted a case-control in Solid cancers (n=791). Nomogram prediction model vs. Khorana score was evaluated on Concordance index (C-index) for predicting venous thromboembolism (95% CI 0.823-0.880, p=<0.05). A novel nomogram demonstrated excellent discrimination for predicting venous thromboembolism in solid cancer patients, achieving a C-index of 0.852 compared to 0.681 for the Khorana score.
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